Benzylamine → HCID 67245096, compound

HRID 2424829Notes

Reaction equation

HRID 2424829 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C@H:10]1[CH2:17][CH2:16][CH2:15][C@:12]2([O:14][CH2:13]2)[CH2:11]1>CO>[CH2:1]([NH:8][CH2:13][C@:12]1([OH:14])[CH2:15][CH2:16][CH2:17][C@H:10]([CH3:9])[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 59808795HCID 59808795, compound

Product 1

HCID 67245096HCID 67245096, compoundYield 69.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A methanol (1 ml) solution of benzylamine (5.9 g) and (3S,5S)-5-methyl-1-oxaspiro[2.5]octane (3.5 g) were heated in a microwave (100 W) for 30 minutes at 100° C., then concentrated in vacuo and purified by flash column chromatography (SiO2, 20% ethyl acetate/iso-hexane as eluent) to afford the subtitle compound as a colourless oil (4.5 g).

Workup

  1. concentrationconcentrated in vacuo
  2. custompurified by flash column chromatography (SiO2, 20% ethyl acetate/iso-hexane as eluent)

Sources & evidence

ORD record
ord-efbecf2010a442b889a6f66a7034ec8f
Source dataset
uspto-grants-2011_06
Patent number
US07964616B2

Reaction notes

Loading…