6-Chloromethyl-2-methylpyridinium chloride → 4-[1-(6-Methyl-pyridin-2-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-chloro-pyridine

HRID 2424866Notes

Reaction equation

HRID 2424866 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.Cl.Cl[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=1>>[CH3:18][C:19]1[N:20]=[C:21]([CH2:25][N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=3)[N:11]=[C:12]2[CH3:15])[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 765456-Chloromethyl-2-methylpyridinium chlorideHCID 178418879HCID 178418879, compound

Product 1

HCID 117716464-[1-(6-Methyl-pyridin-2-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-chloro-pyridine

Procedure

The title compound, MS: m/e=323.2 (M+H+), was prepared in accordance with the general method of example 1 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2-chloromethyl-6-methyl-pyridine hydrochloride.

Sources & evidence

ORD record
ord-d3fe0f7d066f4b4ca1be1c25855988d0
Source dataset
uspto-grants-2011_06
Patent number
US07964620B2

Reaction notes

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