4-(Chloromethyl)-2-methylpyridine hydrochloride → 4-[1-(2-Methyl-pyridin-4-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-chloro-pyridine

HRID 2424880Notes

Reaction equation

HRID 2424880 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.Cl.Cl[CH2:18][C:19]1[CH:24]=[CH:23][N:22]=[C:21]([CH3:25])[CH:20]=1>>[CH3:25][C:21]1[CH:20]=[C:19]([CH2:18][N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=3)[N:11]=[C:12]2[CH3:15])[CH:24]=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 226250444-(Chloromethyl)-2-methylpyridine hydrochlorideHCID 178418879HCID 178418879, compound

Product 1

HCID 865969324-[1-(2-Methyl-pyridin-4-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-chloro-pyridine

Procedure

The title compound, MS: m/e=323.3 (M+H+), was prepared in accordance with the general method of example 1 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 4-chloromethyl-2-methyl-pyridine hydrochloride.

Sources & evidence

ORD record
ord-0cdd197c110a4a8a87c1496f66bf5158
Source dataset
uspto-grants-2011_06
Patent number
US07964620B2

Reaction notes

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