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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424880Generated: October 31, 2026

4-(Chloromethyl)-2-methylpyridine hydrochloride → 4-[1-(2-Methyl-pyridin-4-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-chloro-pyridine

https://huagongshe.com/reaction/2424880

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-methylpyridine hydrochlorideHCID 22625044—
ReactantHCID 178418879HCID 178418879—
Product4-[1-(2-Methyl-pyridin-4-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-chloro-pyridineHCID 86596932—

Reaction Steps

The title compound, MS: m/e=323.3 (M+H+), was prepared in accordance with the general method of example 1 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 4-chloromethyl-2-methyl-pyridine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07964620B2
Source datasetuspto-grants-2011_06
ORD IDord-0cdd197c110a4a8a87c1496f66bf5158
Source noteuspto-grants-2011_06