HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-fluorobenzoyl chloride → HCID 46830662, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-fluorobenzoyl chloride | HCID 2773601 | — |
| Reactant | (S)-N-(1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide | HCID 46220523 | — |
| Product | HCID 46830662 | HCID 46830662 | — |
Reaction Steps
Compound 88 was prepared according to the procedure for the synthesis of compound 36 by replacing 3,4-difluorobenzoyl chloride with 4-chloro-2-fluorobenzoyl chloride. LCMS (+ESI) m/z=453.3 [M+H]+. 1H NMR (CDCl3) δ 7.90 (d, J=9.0 Hz, 1H), 7.67 (t, J=8.1 Hz, 1H), 7.16-7.24 (m, 2H), 6.45 (br, 1H), 4.65 (s, 2H), 4.18 (d, J=9.1 Hz, 1H), 3.94 (t, J=5.6 Hz, 2H), 3.73 (br, 2H), 3.45 (br, 2H), 3.17 (br, 2H), 1.10 (s, 9H). Purity: 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653127B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-75fab7fabb924f75a9aa15e9a1f6b178 |
| Source note | uspto-grants-2014_02 |