[(5-Methyl-1,3,4-oxadiazol-2-yl)methyl]amine → HCID 46862361, compound

Participants

Role	Name	HCID	Charge
Reactant	[(5-Methyl-1,3,4-oxadiazol-2-yl)methyl]amine	HCID 14442192	—
Reactant	(S)-N-(1-(2-cyanoethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide	HCID 46862252	—
Product	HCID 46862361	HCID 46862361	—

Reaction Steps

Compound 113 was prepared by the procedure described for the synthesis of compound 104 by replacing 2-cyanoethylamine with 2-aminomethyl-5-methyl-1,3,4-oxadiazole. LCMS (+ESI) m/z=489.3 [M+H]+. 1H NMR (CDCl3) δ 7.90 (d, J=9.3 Hz, 1H), 7.46-7.52 (m, 1H), 7.28-7.32 (m, 1H), 7.19-7.26 (m, 1H), 6.91 (br, 1H), 4.82 (s, 2H), 4.74-4.79 (m, 1H), 4.58-4.63 (m, 1H), 4.28 (d, J=9.3 Hz, 1H), 3.94 (t, J=5.6 Hz, 2H), 3.17 (br, 2H), 2.51 (s, 3H), 1.12 (s, 9H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08653127B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-ec382a75eeda42c0ad76bf26f53cc37f
Source note	uspto-grants-2014_02