HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → L-(-)-Ornithine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 178464025 | HCID 178464025 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | L-(-)-Ornithine | HCID 6262 | — |
Reaction Steps
Fmoc-Orn(Dde)-OH (386 mg, 0.744 mmol, 4 equiv.), HOBt (114 mg, 0.744 mmol, 4 equiv.) and HBTU (282 mg, 0.744 mmol, 4 equiv.) were dissolved in 2.3 ml DMF. This mixture was let stand at room temperature for 10 min before 0.4 M N-methylmorpholine (in DMF) (3.7 ml, 1.488 mmol, 8 equiv.) was added to it. The resin was treated with this new mixture with gentle rocking for ˜3 h. After the solution was filtered away, the resin was washed three times with DMF (5 ml each time).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964636B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-885f8c3e498c4bf9aca4d6f5ab8f9351 |
| Source note | uspto-grants-2011_06 |