反应详情

Fmoc-Orn(Dde)-OH (386 mg, 0.744 mmol, 4 equiv.), HOBt (114 mg, 0.744 mmol, 4 equiv.) and HBTU (282 mg, 0.744 mmol, 4 equiv.) were dissolved in 2.3 ml DMF. This mixture was let stand at room temperature for 10 min before 0.4 M N-methylmorpholine (in DMF) (3.7 ml, 1.488 mmol, 8 equiv.) was added to it. The resin was treated with this new mixture with gentle rocking for ˜3 h. After the solution was filtered away, the resin was washed three times with DMF (5 ml each time).

1. customat room temperature
2. customfor 10 min
3. additionwas added to it
4. additionThe resin was treated with this new mixture with gentle rocking for ˜3 h
5. filtrationAfter the solution was filtered away
6. washthe resin was washed three times with DMF (5 ml each time)