(5-chloro-2-fluorophenyl)hydrazine → (s)-Tert-butyl 2-(1-(5-chloro-2-fluorophenyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxamido)-3,3-dimethylbutanoate

Participants

Role	Name	HCID	Charge
Reactant	(5-chloro-2-fluorophenyl)hydrazine	HCID 2773732	—
Reactant	L-(+)-Ttert-butyl tert-leuc-inate	HCID 11252445	—
Reactant	(s)-1-(3,4-Difluorophenyl)-n-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxamide	HCID 46863093	—
Product	(s)-Tert-butyl 2-(1-(5-chloro-2-fluorophenyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxamido)-3,3-dimethylbutanoate	HCID 58504324	—

Reaction Steps

This intermediate was prepared according to the procedure escribed for the synthesis of Compound 114 by replacing 3,4-difluorophenylhydrazine with 2-fluoro-5-chlorophenylhydrazine in step 1, and replacing tert-leucine methyl amide with tert-leucine tert-butyl ester in step 3. LC-MS (+ESI) m/z=466.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08653127B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-3ddf0fdf79b141499b63c77621bd3c0e
Source note	uspto-grants-2014_02