5-tert-Butylisophthalic acid → 5-Tert-butyl isophthalic acid 2-ethyl-4-methylimidazole

HRID 242508Notes

Reaction equation

HRID 242508 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])([CH3:4])([CH3:3])[CH3:2].[CH2:17]([C:19]1[NH:20][CH:21]=[C:22]([CH3:24])[N:23]=1)[CH3:18]>CO>[C:1]([C:5]1[CH:6]=[C:7]([C:14]([OH:16])=[O:15])[CH:8]=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])([CH3:4])([CH3:2])[CH3:3].[CH2:17]([C:19]1[NH:20][CH:21]=[C:22]([CH3:24])[N:23]=1)[CH3:18]

Participants

4

Reactant 2

HCID 753795-tert-Butylisophthalic acidHCID 178437635HCID 178437635, compound

Product 1

HCID 1784410905-Tert-butyl isophthalic acid 2-ethyl-4-methylimidazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a 3 L-three neck flask, 180.0 g of 5-tert butyl isophthalic acid and 107.1 g of 2-ethyl-4-methylimidazole, and 810 ml of methanol were added, stirred and heated at reflux for 3 hours. After cooling, by performing filtration and vacuum drying, 201.3 g of the clathrate complex of 5-tert-butyl isophthalic acid/2-ethyl-4-methylimidazole (1:1) was obtained. The clathration of the obtained clathrate complex was confirmed by 1H-NMR, TG-DTA and XRD.

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. temperatureAfter cooling
  4. filtrationfiltration and vacuum
  5. customdrying

Sources & evidence

ORD record
ord-1b6bbaae4eee480daa7852b2bc972542
Source dataset
uspto-grants-2014_02
Patent number
US08653160B2

Reaction notes

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