Hydrochloric Acid → HCID 67245641, compound

HRID 2425115Notes

Reaction equation

HRID 2425115 reaction equation
[ClH:1].[I:2][C:3]1[CH:13]=[C:12]([O:14]C(=O)C)[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6]C(=O)C>C(O)C>[ClH:1].[I:2][C:3]1[CH:13]=[C:12]([OH:14])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67244103HCID 67244103, compound

Product 1

HCID 67245641HCID 67245641, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

37% hydrochloric acid (0.2 ml) was added to a solution of 2-iodo-4-acetyloxy-5-methoxy-N-acetyl-benzylamine (0.1 g, 0.27 mmol) in abs. ethanol (5 ml) and the mixture was refluxed for 12 hours. After cooling, the solvent was evaporated off under reduced pressure and the residue was recrystallized from dry acetone to afford the title compound as pale yellow solid in quantitative yield.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated off under reduced pressure
  3. customthe residue was recrystallized from dry acetone

Sources & evidence

ORD record
ord-be61af6844b7414b9f99f235c34b440e
Source dataset
uspto-grants-2011_06
Patent number
US07964642B2

Reaction notes

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