HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Biphenyl-4-sulfonic acid [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(4-hydroxy-butyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Tert-butyl(2-iodoethoxy)diphenylsilane | HCID 11269862 | — |
| Reactant | N-(4-Hydroxybutyl)[1,1'-biphenyl]-4-sulfonamide | HCID 16094717 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Biphenyl-4-sulfonic acid [2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(4-hydroxy-butyl)-amide | HCID 59728311 | — |
Reaction Steps
Biphenyl-4-sulfonic acid-(4-hydroxybutyl)-amide (1 g) and tert-butyl-(2-iodo-ethoxy) diphenyl silane (2 g) were heated in DMF (30 mL) for 3 hours at 60° C. The resultant mixture was poured into water and extracted with dichloromethane. Evaporation and column chromatography (petrol/ethyl acetate) gave the title compound as an amorphous solid. δC (CDCl3, 62.9 MHz): 19.2, 25.1, 26.8, 29.5, 49.3, 49.8, 62.4, 62.9, 127.3, 127.6, 127.7, 127.8, 128.5, 129.1, 129.9, 133.2, 135.6, 138.4, 139.4 and 145.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964643B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-736f69d73cd14bb1bb13ec7b373d5dea |
| Source note | uspto-grants-2011_06 |