HRID2425124

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID11269862

Silane, (1,1-dimethylethyl)(2-iodoethoxy)diphenyl-

C18H23IOSi

HCID16094717

N-(4-Hydroxybutyl)[1,1'-biphenyl]-4-sulfonamide

C16H19NO3S

PRODUCTS

生成物

结构：CC(C)(C)[Si](OCCN(CCCCO)S(=O)(=O)c1ccc(-c2ccccc2)cc1)(c1ccccc1)c1ccccc1

HCID59728311

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Biphenyl-4-sulfonic acid-(4-hydroxybutyl)-amide (1 g) and tert-butyl-(2-iodo-ethoxy) diphenyl silane (2 g) were heated in DMF (30 mL) for 3 hours at 60° C. The resultant mixture was poured into water and extracted with dichloromethane. Evaporation and column chromatography (petrol/ethyl acetate) gave the title compound as an amorphous solid. δC (CDCl3, 62.9 MHz): 19.2, 25.1, 26.8, 29.5, 49.3, 49.8, 62.4, 62.9, 127.3, 127.6, 127.7, 127.8, 128.5, 129.1, 129.9, 133.2, 135.6, 138.4, 139.4 and 145.3.

WORKUP

后处理

extractionextracted with dichloromethane
customEvaporation and column chromatography (petrol/ethyl acetate)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-736f69d73cd14bb1bb13ec7b373d5dea
来源数据集: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07964643B2
来源说明: uspto-grants-2011_06

反应 SMILES

[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8].[C:22]([Si:26]([O:39][CH2:40][CH2:41]I)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([CH3:25])([CH3:24])[CH3:23].O>CN(C=O)C>[C:22]([Si:26]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[O:39][CH2:40][CH2:41][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][OH:1])[S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:9])=[O:8])([CH3:23])([CH3:24])[CH3:25]