2,4-Difluorophenylboronic acid → HCID 11508373, compound

HRID 2425139Notes

Reaction equation

HRID 2425139 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][CH:11]=1)(=[O:9])=[O:8].[F:17][C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=1B(O)O>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:21]2[CH:20]=[CH:19][C:18]([F:17])=[CH:23][C:22]=2[F:24])=[CH:12][CH:11]=1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 160947204-Bromo-N-(4-hydroxybutyl)benzene-1-sulfonamide

Product 1

HCID 11508373HCID 11508373, compound

Procedure

Using a method analogous to that described in Example 40, 4-bromophenyl-sulfonic acid-(4-hydroxybutyl)-amide and 2,4-difluorophenyl boronic acid were reacted to give the title compound as a white solid. δC (CDCl3, 62.9 MHz): 25.9, 29.6, 42.6, 60.2, 104.7 (t, J 25.8), 112.0 (dd, J 22.9 and 3.5), 127.3, 129.6, 131.5 (d, J 8.8), 131.5 (d, J 9.8), 139.1, 139.4, 159.9 (dd, J 252.0, 11.7) and 163.0 (dd, J 252.0, 11.7).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9b03da13a7a042b39c259d610d442048
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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