4-(Trifluoromethyl)phenylboronic acid → 4'-Trifluoromethylbiphenyl-3-sulfonic acid (4-hydroxy-butyl)-amide

HRID 2425152Notes

Reaction equation

HRID 2425152 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12](Br)[CH:11]=1)(=[O:9])=[O:8].[F:17][C:18]([F:29])([F:28])[C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:11]=[C:12]([C:22]2[CH:23]=[CH:24][C:19]([C:18]([F:29])([F:28])[F:17])=[CH:20][CH:21]=2)[CH:13]=[CH:14][CH:15]=1)(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 597283163-Bromo-N-(4-hydroxybutyl)benzene-1-sulfonamide

Product 1

HCID 115236284'-Trifluoromethylbiphenyl-3-sulfonic acid (4-hydroxy-butyl)-amide

Procedure

Using a method analogous to that described in Example 40, 3-bromophenyl-sulfonic acid-(4-hydroxybutyl)-amide and 4-trifluoromethylphenyl boronic acid were reacted to give the title compound as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5afacd2ee7ed4dc6b71086edbbdce41d
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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