4-Amino-1-butanol → 4-Bromo-N-(4-hydroxybutyl)-2-(trifluoromethyl)benzene-1-sulfonamide

HRID 2425157Notes

Reaction equation

HRID 2425157 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[NH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21]>>[OH:21][CH2:20][CH2:19][CH2:18][CH2:17][NH:16][S:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[C:12]([F:15])([F:14])[F:13])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 258684-Amino-1-butanolHCID 27786084-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride

Product 1

HCID 160947264-Bromo-N-(4-hydroxybutyl)-2-(trifluoromethyl)benzene-1-sulfonamide

Procedure

Using a method analogous to that described in Example 1, 4-bromo-2-trifluoromethylphenyl sulphonyl chloride was reacted with 4-aminobutanol, and the title compound obtained as a white solid after recrystallisation from ether/petrol. δC (CDCl3, 62.9 MHz): 26.5, 29.4, 43.3, 62.1, 127.3, 131.7, 131.7, 133.1, 135.4 and 137.9.

Sources & evidence

ORD record
ord-eefe41f4c99447af8db116e58c9739a7
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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