Phenylboronic Acid → [1,1'-Biphenyl]-4-sulfonamide, N-(4-hydroxybutyl)-3-(trifluoromethyl)-

HRID 2425164Notes

Reaction equation

HRID 2425164 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][C:11]=1[C:17]([F:20])([F:19])[F:18])(=[O:9])=[O:8].[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:12][C:11]=1[C:17]([F:20])([F:19])[F:18])(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 160947264-Bromo-N-(4-hydroxybutyl)-2-(trifluoromethyl)benzene-1-sulfonamide

Product 1

HCID 11574315[1,1'-Biphenyl]-4-sulfonamide, N-(4-hydroxybutyl)-3-(trifluoromethyl)-

Procedure

Using a method analogous to that described in Example 40, 4-bromo-2-trifluoromethylphenyl-sulfonic acid-(4-hydroxybutyl)-amide and phenyl boronic acid were reacted to give the title compound as a white solid. δC (DMSO, 62.9 MHz): 26.1, 29.5, 42.8, 60.2, 125.1, 126.6, 127.2, 127.4, 129.2, 130.8, 132.5, 137.1, 138.3 and 144.0.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-00162857e95b47c694fffccb280fd96f
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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