(2-Nitrophenyl)boronic acid → HCID 11538968, compound

HRID 2425169Notes

Reaction equation

HRID 2425169 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][C:11]=1[C:17]([F:20])([F:19])[F:18])(=[O:9])=[O:8].[N+:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1B(O)O)([O-:23])=[O:22]>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N+:21]([O-:23])=[O:22])=[CH:12][C:11]=1[C:17]([F:20])([F:19])[F:18])(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 2773548(2-Nitrophenyl)boronic acidHCID 160947264-Bromo-N-(4-hydroxybutyl)-2-(trifluoromethyl)benzene-1-sulfonamide

Product 1

HCID 11538968HCID 11538968, compound

Procedure

Using a method analogous to that described in Example 40, 4-bromo-2-trifluoromethylphenyl-sulfonic acid-(4-hydroxybutyl)-amide and 2-nitrophenyl boronic acid were reacted to give the title compound as a thick oil. δC (DMSO, 62.9 MHz): 26.1, 29.5, 42.8, 60.2, 128.2, 124.9, 120.7, 128.7, 130.2, 132.6, 133.1, 133.5, 139.3, 139.8, 141.8 and 147.9.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-77f90c16167444acbb660f48489a5fa8
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

Loading…