反应详情

A solution of 2.0 mmol N-(diphenylmethyl)methylamine, 2.0 mmol (3-phenyl-propionylamino)-acetic acid (CA [56613-60-6]) and 6.0 mmol DIPEA in 10 ml of acetonitrile was treated with 2.2 mmol of TBTU. After 2 hours at room temperature, the reaction mixture was concentrated, diluted with water and extracted 3 times with ethyl acetate. The organic phase was dried and the residue purified by chromatography (SiO2; dichloromethane/methanol) to give the title compound as a slightly yellowish solid.

1. concentrationthe reaction mixture was concentrated
2. additiondiluted with water
3. extractionextracted 3 times with ethyl acetate
4. customThe organic phase was dried
5. customthe residue purified by chromatography (SiO2; dichloromethane/methanol)