反应详情

A solution of 0.2 mmol rac-2-amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride (Example 3.1) and 0.28 mmol of DIPEA in 2 ml of dioxane was treated with 0.2 mmol of benzylisocyanate. The mixture was stirred at room temperature for 48 hours, concentrated and diluted with diethyl ether. The solid was filtered off, dissolved in dichloromethane and extracted 2 times with a diluted solution of citric acid. The organic phase was dried and concentrated. The residue was triturated with diethyl ether to give the title compound as a colorless solid. Yield=93%.

1. concentrationconcentrated
2. additiondiluted with diethyl ether
3. filtrationThe solid was filtered off
4. dissolutiondissolved in dichloromethane
5. extractionextracted 2 times with a diluted solution of citric acid
6. customThe organic phase was dried
7. concentrationconcentrated
8. customThe residue was triturated with diethyl ether