Alanine, N-(4-fluorobenzoyl)- → Rac-4-fluoro-n-((s)-1-{[phenyl-(3-trifluoromethyl-phenyl)-methyl]-carbamoyl}-ethyl)-benzamide

HRID 2425237Notes

Reaction equation

HRID 2425237 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([NH:8][C@@H:9]([CH3:13])[C:10]([OH:12])=O)=[O:7])=[CH:4][CH:3]=1.[C:16]1([CH:22]([NH2:33])[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C@H:9]([C:10](=[O:12])[NH:33][CH:22]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:30])([F:31])[F:32])[CH:24]=2)[CH3:13])=[O:7])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 732160Alanine, N-(4-fluorobenzoyl)-HCID 21528802Phenyl(3-(trifluoromethyl)phenyl)methanamine

Product 1

HCID 59689136Rac-4-fluoro-n-((s)-1-{[phenyl-(3-trifluoromethyl-phenyl)-methyl]-carbamoyl}-ethyl)-benzamide

Procedure

Prepared in analogy to example 1.1 from (S)-2-(4-fluoro-benzoylamino)-propionic acid (CA [214629-12-6]) and rac-C-phenyl-C-(3-trifluoromethyl-phenyl)-methylamine (CA [70428-92-1]).

Sources & evidence

ORD record
ord-d88a1266772647439d1bf6f475c1bd98
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

Loading…