5-Methylthiophene-2-carboxylic acid → 5-Methyl-thiophene-2-carboxylic acid ({[bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-amide

HRID 2425255Notes

Reaction equation

HRID 2425255 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1)=[O:4].[CH3:21][C:22]1[S:26][C:25]([C:27](O)=[O:28])=[CH:24][CH:23]=1>>[F:20][C:16]1[CH:15]=[C:14]([CH:6]([NH:5][C:3]([CH2:2][NH:1][C:27]([C:25]2[S:26][C:22]([CH3:21])=[CH:23][CH:24]=2)=[O:28])=[O:4])[C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 747135-Methylthiophene-2-carboxylic acidHCID 596891532-amino-N-[bis-(3-fluoro-phenyl)-methyl]-acetamide

Product 1

HCID 248967755-Methyl-thiophene-2-carboxylic acid ({[bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-amide

Procedure

Prepared in analogy to example 1.12 from 2-amino-N-[bis-(3-fluoro-phenyl)-methyl]-acetamide (example 3.4) and 5-methyl-thiophene-2-carboxylic acid.

Sources & evidence

ORD record
ord-e6be05c8605c49079a59a4333f6b8edc
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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