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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2425270Generated: October 28, 2026

Hydrochloric Acid → 2-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride

https://huagongshe.com/reaction/2425270

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl esterHCID 59689146—
SolventDiethyl EtherHCID 3283—
Product2-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochlorideHCID 67246438100%

Reaction Steps

6.6 mmol ({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester were treated with 30 ml of a saturated solution of hydrogen chloride in diethyl ether. The mixture was stirred at room temperature for 1 hour. Removal of the diethyl ether in the rotatory evaporator yields the title compound as a colorless solid. Yield=100%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07964645B2
Source datasetuspto-grants-2011_06
ORD IDord-89b0d6a4a01a4fafb5e7dca0957c0d82
Source noteuspto-grants-2011_06