Hydrochloric Acid → 2-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochloride

HRID 2425270Notes

Reaction equation

HRID 2425270 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9](=[O:25])[NH:10][CH:11]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(C)(C)C.Cl>C(OCC)C>[ClH:24].[NH2:7][CH2:8][C:9]([NH:10][CH:11]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59689146({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester

Product 1

HCID 672464382-Amino-N-[(4-chloro-phenyl)-phenyl-methyl]-acetamide hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

6.6 mmol ({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester were treated with 30 ml of a saturated solution of hydrogen chloride in diethyl ether. The mixture was stirred at room temperature for 1 hour. Removal of the diethyl ether in the rotatory evaporator yields the title compound as a colorless solid. Yield=100%.

Workup

  1. customRemoval of the diethyl ether
  2. customin the rotatory evaporator

Sources & evidence

ORD record
ord-89b0d6a4a01a4fafb5e7dca0957c0d82
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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