Sodium Carbonate → HCID 135991366, compound

HRID 2425274Notes

Reaction equation

HRID 2425274 reaction equation
[C:1]1([C:7]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][OH:16].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]1([C:7]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[N:15][OH:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 5699672-Benzoylthiazole

Product 1

HCID 135991366HCID 135991366, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To Phenyl-thiazol-2-yl-methanone (0.5 g) in ethanol (6 mL) was added hydroxylamine hydrochloride (3 eq) and sodiumcarbonate (3 eq). The reaction mixture was stirred at reflux overnight and then allowed to cool down to room temperature. The precipitate was then isolated by filtration and washed with water to yield the title compound as a light grey solid. MS (m/e): 207.1 (5), 206.1 (10), 205.1 (100% M+H+)

Workup

  1. temperatureat reflux overnight
  2. customThe precipitate was then isolated by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-51769e68e5f548c19cbc3eb616bfdd9d
Source dataset
uspto-grants-2011_06
Patent number
US07964645B2

Reaction notes

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