Bromine → HCID 67246500, compound

HRID 2425316Notes

Reaction equation

HRID 2425316 reaction equation
[CH2:1]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[CH2:13][CH2:12]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:13]1[CH2:12][C:11]2[C:15](=[CH:16][CH:17]=[C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:10]=2)[C:14]1=[O:18]

Participants

4

Reactant 2

HCID 24408BromineHCID 67248522HCID 67248522, compound

Product 1

HCID 67246500HCID 67246500, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 2 (1.094 g, 4.48 mmol) in CHCl3 (10 mL) at 40° C. was added Br2 (0.23 mL, 4.477 mmol) dropwise over 15 minutes. The reaction was left to stir for 30 minutes. The resulting solution was concentrated and purified with silica gel chromatography eluding with hexanes-EtOAc (9:1). The reaction provided 3 (1.212 g, 3.75 mmol, 84%) as an orange liquid.

Workup

  1. waitThe reaction was left
  2. concentrationThe resulting solution was concentrated
  3. custompurified with silica gel chromatography

Sources & evidence

ORD record
ord-36f6bae739ec4cc2847bb8c17991aae6
Source dataset
uspto-grants-2011_06
Patent number
US07964649B2

Reaction notes

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