6-[(2-Methylbut-3-yn-2-yl)oxy]quinoline → HCID 639605, compound

HRID 2425343Notes

Reaction equation

HRID 2425343 reaction equation
[CH3:1][C:2]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)([CH3:5])[C:3]#[CH:4]>ClC1C=CC=CC=1Cl>[CH3:5][C:2]1([CH3:1])[O:6][C:7]2[C:8](=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[CH:10]3)[CH:4]=[CH:3]1

Participants

3

Reactant 1

HCID 591343216-[(2-Methylbut-3-yn-2-yl)oxy]quinoline

Product 1

HCID 639605HCID 639605, compound

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

A solution of 6-[(1,1-dimethyl-2-propynyl)oxy]quinoline (16.7 mmol) in 1,2-dichlorobenzene (10 mL) was stirred at 180° C. for 1 hour. Upon the completion of the reaction, the solvent was distilled off, and the residue was recrystallized with hexane-ethyl acetate to obtain the aimed compound (2-step, quant.).

Workup

  1. customUpon the completion of the reaction
  2. distillationthe solvent was distilled off
  3. customthe residue was recrystallized with hexane-ethyl acetate

Sources & evidence

ORD record
ord-0934440df4864270884be38b3fd067a4
Source dataset
uspto-grants-2011_06
Patent number
US07964623B2

Reaction notes

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