Ethanol → HCID 68424421, compound

HRID 2425363Notes

Reaction equation

HRID 2425363 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[C:25]([N+:26]([O-])=O)=[CH:24][C:8]2[CH:9]([NH:15][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:10][C:11]([CH3:14])([CH3:13])[O:12][C:7]=2[CH:6]=1.C([OH:31])C>[C].[Pd]>[NH2:26][C:25]1[C:5]([O:4][CH2:3][O:2][CH3:1])=[CH:6][C:7]2[O:12][C:11]([CH3:14])([CH3:13])[C@@H:10]([OH:31])[C@H:9]([NH:15][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:8]=2[CH:24]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 67246646HCID 67246646, compound

Product 1

HCID 68424421HCID 68424421, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

To a solution of 7-methoxymethoxy-2,2-dimethyl-6-nitro-4-(2-phenylethylamino)-3,4-dihydro-2H-1-benzopyrane (265 mg, 0.66 mmol) in ethanol (5 mL), 5% palladium-carbon (AER type, 13 mg) was added at room temperature, and the resulting mixture was stirred under hydrogen stream overnight. Upon the completion of the reaction, the resulting solution was filtered through celite, concentrated, and the aimed product was obtained (yield: 98%).

Workup

  1. customUpon the completion of the reaction
  2. filtrationthe resulting solution was filtered through celite,
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-c99fdaf319c640889039f9562197c972
Source dataset
uspto-grants-2011_06
Patent number
US07964623B2

Reaction notes

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