Hydrochloride methanol → Hydrochloric Acid

HRID 2425382Notes

Reaction equation

HRID 2425382 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:29])=[CH:20][N:21]=[C:22]([O:27]C)[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:30].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:29])=[CH:20][N:21]=[C:22]([OH:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:30]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67243856HCID 67243856, compound

Product 2

HCID 313Hydrochloric AcidHCID 178511748HCID 178511748, compound

Conditions

Temperature
50 °C

Procedure

Intermediate 4a (25 mg) obtained in Example 6-1, Step B was added with 10% hydrogen chloride/methanol (10 ml), and the mixture was stirred at 50° C. for 50 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (13 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-31fdc3fa822b4aea82553fcc7f5c71b6
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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