Hydrochloride methanol → Hydrochloric Acid

HRID 2425401Notes

Reaction equation

C(O[C:6]([N:8]([C@H:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Br:28])=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)C)=O)(C)(C)C.[ClH:29].CO>>[Br:28][C:20]1[C:19]2[C:18]([S:15]([N:12]3[CH2:13][CH2:14][C@H:10]([NH:8][CH3:6])[CH2:11]3)(=[O:16])=[O:17])=[CH:27][CH:26]=[CH:25][C:24]=2[CH:23]=[N:22][CH:21]=1.[ClH:29]

Participants

Reactant 2

HCID 21893726Hydrochloride methanol

HCID 67245309HCID 67245309, compound

Product 2

HCID 313Hydrochloric Acid

HCID 67243898HCID 67243898, compound

Procedure

Intermediate 20a (0.157 g) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml), and the mixture was stirred at room temperature for 12 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (125 mg).

Workup

customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record: ord-40f77882683d493db04fc44236c65065
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07964613B2

Reaction notes

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