反应详情

(S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 27a) can be prepared by using 1-chloro-4-fluoro-5-isoquinolinesulfonyl chloride in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride, and then used in the method of Step B in a similar manner to obtain the title compound as hydrochloride.