tert-butyl N-(pyrrolidin-3-yl)carbamate → Hydrochloric Acid

Participants

Role	Name	HCID	Charge
Reactant	tert-butyl N-(pyrrolidin-3-yl)carbamate	HCID 2757234	—
Reactant	(S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester	HCID 7171888	—
Reactant	(r/s)-3-(Tert-butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine	HCID 87322137	—
Product	Hydrochloric Acid	HCID 313	—
Product	(r/s)-3-Amino-1-(1-amino-4-bromo-5-isoquinolinesulfonyl)pyrrolidine	HCID 67243187	—

Reaction Steps

(R/S)-3-(tert-Butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine can be prepared by using 3-(tert-butoxycarbonylamino)pyrrolidine in the method of Example 35-1, Step A instead of (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, and then the protective group of the obtained compound can be removed according to the method described in Example 39-1, Step B to obtain the title compound as hydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07964613B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-5863bf190d5c49d8a8e4076da38c67eb
Source note	uspto-grants-2011_06