1,4-Dioxane hydrochloride → Hydrochloric Acid

Participants

Reaction Steps

Intermediate 33a (16.3 mg) prepared in Step A mentioned above was added with 4 N hydrogen chloride/1,4-dioxane solution (2 ml, Kokusan Chemical), and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (13.3 mg).

Provenance & Evidence