1,4-Dioxane hydrochloride → Hydrochloric Acid

HRID 2425432Notes

Reaction equation

HRID 2425432 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([C:27]([F:30])([F:29])[F:28])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:31].O1CCOCC1>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([C:27]([F:30])([F:29])[F:28])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:31]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67246418HCID 67246418, compound

Product 2

HCID 313Hydrochloric AcidHCID 67242802HCID 67242802, compound

Procedure

Intermediate 33a (16.3 mg) prepared in Step A mentioned above was added with 4 N hydrogen chloride/1,4-dioxane solution (2 ml, Kokusan Chemical), and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (13.3 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b7a4b5ef20a84d0da9a01172d3d401f4
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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