Trifluoroacetic acid → Trifluoroacetate

HRID 2425436Notes

Reaction equation

HRID 2425436 reaction equation
C(O[C:6]([N:8]([C@H:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Cl:31])=[CH:21][N:22]=[C:23]([O:28][CH2:29][CH3:30])[C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)C)=O)(C)(C)C.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>ClCCl>[CH3:6][NH:8][C@H:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Cl:31])=[CH:21][N:22]=[C:23]([O:28][CH2:29][CH3:30])[C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:16])=[O:17])[CH2:11]1.[F:32][C:33]([F:38])([F:37])[C:34]([O-:36])=[O:35]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67242702(S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-ethoxy-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

Product 2

HCID 84468TrifluoroacetateHCID 67245217(S)-3-(Methylamino)-1-(1-ethoxy-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Intermediate 38a (141 mg) obtained in Step A was dissolved in a solution of trifluoroacetic acid (0.9 ml, Aldrich) in dichloromethane (2.1 ml), and the solution was stirred at room temperature 5 hours. The solvent was evaporated under reduced pressure to obtain the title compound as trifluoroacetate (145 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-75b688f3e8b74de89c6b8e1be1a19c92
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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