HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514396 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Reactant | HCID 67243109 | HCID 67243109 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 67243949 | HCID 67243949 | — |
Reaction Steps
4-Chloro-5-isoquinolinesulfonyl chloride obtained in Reference Example 7 and 2-(tert-butoxycarbonylaminomethyl)piperidine (Aldrich) were used in the method of Example 1-1, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-(tert-butoxycarbonylamino)pyrrolidine, respectively, to prepare 2-[(tert-butoxycarbonylamino) methyl]-1-(4-chloro-5-isoquinolinesulfonyl)piperidine, and then the resultant was used in the method of Example 1-1, Step B to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964613B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-8915ee0954b946b08a6ec314f23e4417 |
| Source note | uspto-grants-2011_06 |