(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → Hydrochloric Acid

HRID 2425441Notes

Reaction equation

HRID 2425441 reaction equation
BrC1C2C(S([Cl:15])(=O)=O)=CC=CC=2C=NC=1.C(OC(N[C@H]1CCNC1)=O)(C)(C)C.C(OC([NH:36][CH2:37][CH:38]1[CH2:43][CH2:42][CH2:41][CH2:40][N:39]1[S:44]([C:47]1[C:48]2[C:49]([Cl:57])=[CH:50][N:51]=[CH:52][C:53]=2[CH:54]=[CH:55][CH:56]=1)(=[O:46])=[O:45])=O)(C)(C)C>>[NH2:36][CH2:37][CH:38]1[CH2:43][CH2:42][CH2:41][CH2:40][N:39]1[S:44]([C:47]1[C:48]2[C:49]([Cl:57])=[CH:50][N:51]=[CH:52][C:53]=2[CH:54]=[CH:55][CH:56]=1)(=[O:46])=[O:45].[ClH:15]

Participants

5

Reactant 3

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 145800584-Bromo-5-isoquinolinesulfonyl chlorideHCID 67243109HCID 67243109, compound

Product 2

HCID 313Hydrochloric AcidHCID 67243949HCID 67243949, compound

Procedure

4-Chloro-5-isoquinolinesulfonyl chloride obtained in Reference Example 7 and 2-(tert-butoxycarbonylaminomethyl)piperidine (Aldrich) were used in the method of Example 1-1, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-(tert-butoxycarbonylamino)pyrrolidine, respectively, to prepare 2-[(tert-butoxycarbonylamino) methyl]-1-(4-chloro-5-isoquinolinesulfonyl)piperidine, and then the resultant was used in the method of Example 1-1, Step B to obtain the title compound as hydrochloride.

Sources & evidence

ORD record
ord-8915ee0954b946b08a6ec314f23e4417
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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