HCID 67244849, compound → HCID 67243255, compound

HRID 2425449Notes

Reaction equation

HRID 2425449 reaction equation
C([O:8][CH2:9][CH2:10][O:11][CH2:12][C:13]([NH:15][C@H:16]1[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17]1)=[O:14])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][CH2:9][CH2:10][O:11][CH2:12][C:13]([NH:15][C@H:16]1[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17]1)=[O:14]

Participants

4

Reactant 1

HCID 67244849HCID 67244849, compound

Product 1

HCID 67243255HCID 67243255, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of (S)-3-[2-[2-(benzyloxy)ethoxy]acetyl]amino-1-(tert-butoxycarbonyl)pyrrolidine (25 g) prepared in Step B in ethanol (150 ml) was added with 10% palladium/carbon (2.5 g, Merck), and the mixture was stirred at room temperature for 4 hours under a hydrogen atmosphere. The atmosphere in the reaction vessel was replaced with nitrogen gas, then the insoluble solids were removed by filtration through Celite, and the solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. customthe insoluble solids were removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5ea0a225468b47e990536d5db050a1b5
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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