Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 2-[[2-(dimethylamino)ethyl] (methyl)amino]acetate (1.25 g) prepared in Step A was added with 4 N hydrogen chloride (solution in 1,4-dioxane, 15 ml), and the mixture was stirred at 60° C. for 6 hours. The reaction mixture was cooled to room temperature, and the deposited solids were taken by filtration, washed with diethyl ether, and then dried under reduced pressure to obtain the title compound as hydrochloride (886 mg).

Provenance & Evidence