Hydrochloric Acid → Hydrochloric Acid

HRID 2425455Notes

Reaction equation

HRID 2425455 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]([CH3:14])[CH2:6][C:7]([O:9]C(C)(C)C)=[O:8].[ClH:16]>>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]([CH3:14])[CH2:6][C:7]([OH:9])=[O:8].[ClH:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86627815HCID 86627815, compound

Product 2

HCID 313Hydrochloric AcidHCID 17774209HCID 17774209, compound

Conditions

Temperature
60 °C

Procedure

tert-Butyl 2-[[2-(dimethylamino)ethyl] (methyl)amino]acetate (1.25 g) prepared in Step A was added with 4 N hydrogen chloride (solution in 1,4-dioxane, 15 ml), and the mixture was stirred at 60° C. for 6 hours. The reaction mixture was cooled to room temperature, and the deposited solids were taken by filtration, washed with diethyl ether, and then dried under reduced pressure to obtain the title compound as hydrochloride (886 mg).

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe deposited solids were taken by filtration
  3. washwashed with diethyl ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-18437ca4ae6e4ccfa6ea34bce4d26bb6
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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