Hydrochloric Acid → Hydrochloric Acid

HRID 2425458Notes

Reaction equation

HRID 2425458 reaction equation
[N:1]1([CH2:5][C:6]([O:8]C(C)(C)C)=[O:7])[CH2:4][CH2:3][CH2:2]1.[ClH:13]>>[N:1]1([CH2:5][C:6]([OH:8])=[O:7])[CH2:4][CH2:3][CH2:2]1.[ClH:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68945104HCID 68945104, compound

Product 2

HCID 313Hydrochloric AcidHCID 18923029HCID 18923029, compound

Procedure

tert-Butyl 2-(azetidin-1-yl)acetate (688 mg) prepared in Step A mentioned above was added with 4 N hydrogen chloride (solution in 1,4-dioxane, 10 ml), and the mixture was stirred at room temperature for 20 hours. The deposited solids were taken by filtration, washed with diethyl ether, and then dried under reduced pressure to obtain the title compound as hydrochloride (574 mg).

Workup

  1. filtrationThe deposited solids were taken by filtration
  2. washwashed with diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-889022ba4e684c669c740ed6a56df441
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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