Trifluoroacetic acid → Trifluoroacetate

HRID 2425460Notes

Reaction equation

HRID 2425460 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([NH:10][C@H:11]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)=[O:9])[CH2:3]1.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([NH:10][C@H:11]2[CH2:15][CH2:14][NH:13][CH2:12]2)=[O:9])[CH2:3]1.[F:23][C:24]([F:29])([F:28])[C:25]([O-:27])=[O:26]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67244239HCID 67244239, compound

Product 2

HCID 84468TrifluoroacetateHCID 67242646HCID 67242646, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(S)-3-[2-(3-Hydroxypyrrolidin-1-yl)acetyl]amino-1-(tert-butoxycarbonyl)pyrrolidine (531 mg) prepared in Step A mentioned above was added with a 30% solution of trifluoroacetic acid in dichloromethane (8 ml), and the mixture was stirred at room temperature for 2 hours. The volatile components were evaporated under reduced pressure to obtain the title compound as trifluoroacetate (900 mg).

Workup

  1. customThe volatile components were evaporated under reduced pressure

Sources & evidence

ORD record
ord-0832008bfa8b4231b4b408c2029e264c
Source dataset
uspto-grants-2011_06
Patent number
US07964613B2

Reaction notes

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