HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67180429, compound → 1-(5-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67180429 | HCID 67180429 | — |
| Reactant | 1-(5-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanone | HCID 67182258 | — |
| Product | 1-(5-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanamine dihydrochloride | HCID 67183212 | 99% |
Reaction Steps
The title compound was prepared in >99% yield by the same process as described for (R)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethanamine dihydrochloride (Amine 2) using 1-(5-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)ethanone (Step A6A) as a starting material. 1H NMR (300 MHz, DMSO-d6) δ 1.49 (3H, d, J=6.0 Hz), 2.32 (3H, s), 4.29-4.33 (1H, m), 5.07 (1H, d, J=9.0 Hz), 5.13 (1H, d, J=9.0 Hz), 7.72 (1H, s), 8.34 (3H, brs).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964732B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-09bfe4e0c8324e11993ca8283bc30a3b |
| Source note | uspto-grants-2011_06 |