HCID 136335061, compound → HCID 67182627, compound

HRID 2425549Notes

Reaction equation

HRID 2425549 reaction equation
[CH3:1][C:2]([S:5](/[N:7]=[CH:8]/[C:9]1[CH:10]=[N:11][NH:12][C:13]=1[CH3:14])=[O:6])([CH3:4])[CH3:3].[CH3:15][Mg+].[Br-]>C1COCC1>[CH3:4][C:2]([S:5]([NH:7][CH:8]([C:9]1[CH:10]=[N:11][NH:12][C:13]=1[CH3:14])[CH3:15])=[O:6])([CH3:1])[CH3:3]

Participants

4

Reactant 2

HCID 136335061HCID 136335061, compoundHCID 178418689HCID 178418689, compound

Product 1

HCID 67182627HCID 67182627, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of (E)-2-methyl-N-((5-methyl-1H-pyrazol-4-yl)methylene)propane-2-sulfinamide (Step A9B) (2.1 g, 9.29 mmol) in THF (45 ml) was added a 1M solution of MeMgBr in THF (27.9 ml, 27.9 mmol) at −48° C. under nitrogen. After being stirred for 60 min, the reaction mixture was allowed to warm to rt and then heated at 90° C. for 4 hours.

Workup

  1. temperatureheated at 90° C. for 4 hours

Sources & evidence

ORD record
ord-410a340a8fc0484da6bdea61e17185e2
Source dataset
uspto-grants-2011_06
Patent number
US07964732B2

Reaction notes

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