反应详情

To a solution of (E)-2-methyl-N-((5-methyl-1H-pyrazol-4-yl)methylene)propane-2-sulfinamide (Step A9B) (2.1 g, 9.29 mmol) in THF (45 ml) was added a 1M solution of MeMgBr in THF (27.9 ml, 27.9 mmol) at −48° C. under nitrogen. After being stirred for 60 min, the reaction mixture was allowed to warm to rt and then heated at 90° C. for 4 hours.

1. temperatureheated at 90° C. for 4 hours