Sodium Hydroxide → HCID 20627927, compound

HRID 2425563Notes

Reaction equation

HRID 2425563 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([O:17]C)=[O:16])[CH:9]=[CH:8]2)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([OH:17])=[O:16])[CH:9]=[CH:8]2)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57458159HCID 57458159, compound

Product 1

HCID 20627927HCID 20627927, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 6-tert-butyl-2-naphthoate (Step CA2A)(843 mg, 3.48 mmol) and 2M sodium hydroxide solution (6.96 mmol, 3.48 mmol) in methanol (30 ml) was treated according to the procedure described in step CA1G to furnish the title compound as a white solid (614 mg, 77%). 1H NMR (270 MHz, DMSO-d6): 1.39 (9H, s), 7.70-7.76 (1H, m), 7.90-8.08 (4H, m), 8.55 (1H, br, s), 13.00 (1H, br, s).

Workup

  1. additionwas treated

Sources & evidence

ORD record
ord-5e685d47e61348d1a7b40728b928c374
Source dataset
uspto-grants-2011_06
Patent number
US07964732B2

Reaction notes

Loading…