反应详情

To a solution of 4-(4-Chloro-phenyl)-4-hydroxy-3-methyl-piperidine-1-carboxylic acid tert-butyl ester (1.5 g, 4.6 mmol) in dichloromethane (40 mL) at about 0° C. was added trifluoroacetic acid (10 mL). The solution was stirred for about 2 hours. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was neutralized with saturated sodium bicarbonate, and washed with brine and dried over magnesium sulfate. The solvent was removed to give a yellow solid. No purification was needed.

1. customThe solvent was evaporated
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was removed
6. customto give a yellow solid
7. customNo purification