Hydrochloric Acid → 1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride

HRID 2425601Notes

Reaction equation

HRID 2425601 reaction equation
[ClH:1].[F:2][C:3]([F:19])([F:18])[CH2:4][N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1>O1CCOCC1>[ClH:1].[ClH:1].[F:19][C:3]([F:2])([F:18])[CH2:4][N:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 16748694Tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate

Product 1

HCID 163120671-(2,2,2-Trifluoroethyl)piperazine dihydrochlorideYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of hydrochloric acid (4.0 M, 10 mL) in dioxane was added to a solution of tert-butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate (0.736 g, 2.74 mmol) in dioxane (5 mL). The reaction mixture was stirred until analysis by thin layer chromatography indicated completion of reaction (approx. 3 h). The volatiles were evaporated and the residue was dried under vacuum to yield 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride (0.631 g, 95%) as a white solid.

Workup

  1. customcompletion of reaction (approx. 3 h)
  2. customThe volatiles were evaporated
  3. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-66c70463316b4c86afc857c083f45ef4
Source dataset
uspto-grants-2011_06
Patent number
US07964724B2

Reaction notes

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