tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate → 2-[4-(4-Chloro-phenyl)-piperidin-4-yl]-propan-2-ol

HRID 242570Notes

Reaction equation

HRID 242570 reaction equation
C(OC(N1CCC(C2C=CC(Cl)=CC=2)(C#N)CC1)=O)(C)(C)C.C(OC([N:30]1[CH2:35][CH2:34][C:33]([C:40]2[CH:45]=[CH:44][C:43]([Cl:46])=[CH:42][CH:41]=2)([C:36]([OH:39])([CH3:38])[CH3:37])[CH2:32][CH2:31]1)=O)(C)(C)C>>[Cl:46][C:43]1[CH:44]=[CH:45][C:40]([C:33]2([C:36]([OH:39])([CH3:37])[CH3:38])[CH2:34][CH2:35][NH:30][CH2:31][CH2:32]2)=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 49760270tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylateHCID 667585124-(4-Chloro-phenyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 231368852-[4-(4-Chloro-phenyl)-piperidin-4-yl]-propan-2-ol

Procedure

The title compound was prepared by following the procedure of Example 456, step 3, but replacing 4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester with: 4-(4-chloro-phenyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-34c244834907471f85c850fc1f2ecf37
Source dataset
uspto-grants-2014_02
Patent number
US08653096B2

Reaction notes

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