tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate → 2-[4-(4-Chloro-phenyl)-piperidin-4-yl]-propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate	HCID 49760270	—
Reactant	4-(4-Chloro-phenyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester	HCID 66758512	—
Product	2-[4-(4-Chloro-phenyl)-piperidin-4-yl]-propan-2-ol	HCID 23136885	—

Reaction Steps

The title compound was prepared by following the procedure of Example 456, step 3, but replacing 4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester with: 4-(4-chloro-phenyl)-4-(1-hydroxy-1-methyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08653096B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-34c244834907471f85c850fc1f2ecf37
Source note	uspto-grants-2014_02