1-(2-Methanesulfonylethyl)piperazine dihydrochloride → HCID 86761343, compound

HRID 2425709Notes

Reaction equation

HRID 2425709 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:30](Cl)=[O:31])[C@H:13]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)[C@H:14]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:15]=2)=[C:7]([O:33][CH2:34][C:35]([F:38])([F:37])[F:36])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[CH3:41][S:42]([CH2:45][CH2:46][N:47]1[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]1)(=[O:44])=[O:43]>>[ClH:22].[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:30]([N:50]3[CH2:49][CH2:48][N:47]([CH2:46][CH2:45][S:42]([CH3:41])(=[O:43])=[O:44])[CH2:52][CH2:51]3)=[O:31])[C@H:13]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)[C@H:14]([C:16]3[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=3)[N:15]=2)=[C:7]([O:33][CH2:34][C:35]([F:37])([F:38])[F:36])[CH:6]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 177498851-(2-Methanesulfonylethyl)piperazine dihydrochlorideHCID 86761342HCID 86761342, compound

Product 1

HCID 86761343HCID 86761343, compound

Procedure

[(4S,5R)-2-[4-tert-Butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride was prepared from (4S,5R)-2-[4-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 12l) and 1-(2-methanesulfonylethyl)piperazine dihydrochloride (example 17) in an analogous manner as described in example 25. LR-MS: 739.4 [(M+H)+]

Sources & evidence

ORD record
ord-8862c74bc2ae4d369d0755d3012fb61d
Source dataset
uspto-grants-2011_06
Patent number
US07964724B2

Reaction notes

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